Histologic Evidence of Intrapulmonary Bronchopulmonary Anastomotic Pathways in Neonates with Meconium Aspiration Syndrome

Noorjahan Ali; Steven H Abman; Csaba Galambos

doi:10.1016/j.jpeds.2015.08.049

Histologic Evidence of Intrapulmonary Bronchopulmonary Anastomotic Pathways in Neonates with Meconium Aspiration Syndrome

J Pediatr. 2015 Dec;167(6):1445-7. doi: 10.1016/j.jpeds.2015.08.049. Epub 2015 Sep 28.

Authors

Noorjahan Ali¹, Steven H Abman², Csaba Galambos³

Affiliations

¹ Department of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO; Pediatric Heart Lung Center, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO. Electronic address: noorjahan.ali@childrenscolorado.org.
² Department of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO; Pediatric Heart Lung Center, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO.
³ Pediatric Heart Lung Center, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO; Department of Pathology & Laboratory Medicine, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO.

PMID: 26421487
DOI: 10.1016/j.jpeds.2015.08.049

Abstract

We examined lung histology from 8 infants who died with meconium aspiration syndrome in order to determine the presence of intrapulmonary bronchopulmonary anastomotic pathways. Each infant required mechanical ventilation to treat hypoxemic respiratory distress. Lung histology from each infant shows evidence of prominent bronchopulmonary vascular connections.

MeSH terms

Arteriovenous Anastomosis / pathology*
Female
Humans
Infant, Newborn
Lung / blood supply*
Lung / pathology
Male
Meconium Aspiration Syndrome / pathology*
Pulmonary Circulation
Retrospective Studies
Severity of Illness Index