We have studied 42 unselected patients with a clinical diagnosis of multiple sclerosis (MS) for clinical and laboratory features of Sjogren's syndrome (SS). The MS patients in this study had similar demographic/epidemiologic features as those previously reported in the literature. The most striking features of the MS patients suggesting a SS diathesis was the presence of dry eyes (xeropthalmia) in six (14%). Although 2/6 of the symptomatic patients and 6/36 of the asymptomatic patients had abnormal tear production (Schirmer's test) this was accounted for by the concomitant use of anti-cholinergic medication. None of the MS patients had autoantibodies (SS-A/Ro, SS-B/La, rheumatoid factor) thought to be characteristic of SS. We conclude that SS, either in isolation or occurring in combination with MS, is uncommon in an MS outpatient setting.