Abstract
N-Protected amino acids can be easily converted into chiral α-amino aldehydes in a one-pot reaction by activation with CDI followed by reduction with DIBAL-H. This method delivers Boc-, Cbz- and Fmoc-protected amino aldehydes from proteinogenic amino acids in very good isolated yields and complete stereointegrity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aldehydes / chemical synthesis*
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Aldehydes / chemistry
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Amino Acids / chemistry*
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Imidazoles / chemistry*
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Organometallic Compounds / chemistry*
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Oxidation-Reduction
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Time Factors
Substances
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Aldehydes
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Amino Acids
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Imidazoles
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Organometallic Compounds
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N,N-carbonyldiimidazole
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diisobutylaluminum