TERT Polymorphism rs2853669 Influences on Lung Cancer Risk in the Korean Population

J Korean Med Sci. 2015 Oct;30(10):1423-8. doi: 10.3346/jkms.2015.30.10.1423. Epub 2015 Sep 12.


Short telomeres are known as one of the risk factors for human cancers. The present study was conducted to evaluate the association between 6 polymorphisms, which were related with short telomere length in the Korean population, and lung cancer risk using 1,100 cases and 1,096 controls. Among the 6 polymorphisms, TERT rs2853669 was significantly associated with increased lung cancer risk under a recessive model (odds ratio [OR]=1.38, 95% confidence interval [CI]=1.05-1.81, P=0.02). The effect of rs2853669 on lung cancer risk was significant in younger individuals (OR=1.73, 95% CI=1.18-2.54, P=0.005) and adenocarcinoma (OR=1.50, 95% CI=1.07-2.07, P=0.02). Our results suggest that a common functional promoter polymorphism, TERT rs2853669, may influence both telomere length and lung cancer risk in the Korean population.

Keywords: Lung Cancer Risk; Polymorphism; TERT; Telomere Length.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / epidemiology
  • Adenocarcinoma / genetics*
  • Case-Control Studies
  • Female
  • Gene Frequency / genetics
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Humans
  • Lung Neoplasms / epidemiology
  • Lung Neoplasms / genetics*
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide / genetics*
  • Promoter Regions, Genetic / genetics*
  • Republic of Korea / epidemiology
  • Telomerase / genetics*
  • Telomere / physiology
  • Telomere Homeostasis / genetics*


  • TERT protein, human
  • Telomerase