Cyclophosphamide-Induced Cardiomyopathy: A Case Report, Review, and Recommendations for Management

J Investig Med High Impact Case Rep. 2013 Jan 1;1(1):2324709613480346. doi: 10.1177/2324709613480346. eCollection 2013 Jan-Mar.


Cyclophosphamide is increasingly used to treat various types of cancers and autoimmune conditions. Higher doses of this drug may produce significant cardiac toxicity, including fatal hemorrhagic myocarditis. In this review, we present a case of cyclophosphamide-induced cardiomyopathy requiring mechanical circulatory support. We also describe the pathophysiology, clinical manifestations, and risk factors for this important clinical entity and propose early detection and management strategies.

Keywords: cardiomyopathy; cardiotoxicity; cyclophosphamide; heart failure; mechanical circulatory support; myocarditis.