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Clinical Trial
. 1989 Jan;40(1):34-7.
doi: 10.1002/jso.2930400109.

Controlled Clinical Trial of Adjuvant Immunotherapy With BCG and Neuraminidase-Treated Autologous Tumour Cells in Large Bowel Cancer

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Clinical Trial

Controlled Clinical Trial of Adjuvant Immunotherapy With BCG and Neuraminidase-Treated Autologous Tumour Cells in Large Bowel Cancer

B N Gray et al. J Surg Oncol. .

Abstract

A controlled, randomised clinical trial of immunotherapy was performed in 301 patients with stage B or C colorectal cancer. The immunotherapy treatment consisted of 18 vaccinations over a 2 year period following surgery with a combination of BCG given by scarification plus subcutaneous injection of Vibrio cholera neuraminidase (VCN)-modified autologous tumour cells. Five year follow-up has now been completed in all patients. The immunotherapy did not alter either the disease-free interval or the overall survival of patients in comparison with a control group of patients not receiving immunotherapy.

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