Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 5 (4), 2223-46

Impact of Alcohol on Glycemic Control and Insulin Action

Affiliations
Review

Impact of Alcohol on Glycemic Control and Insulin Action

Jennifer L Steiner et al. Biomolecules.

Abstract

Alcohol has profound effects on tissue and whole-body fuel metabolism which contribute to the increased morbidity and mortality in individuals with alcohol use disorder. This review focuses on the glucose metabolic effects of alcohol, primarily in the muscle, liver and adipose tissue, under basal postabsorptive conditions and in response to insulin stimulation. While there is a relatively extensive literature in this area, results are often discordant and extrapolating between models and tissues is fraught with uncertainty. Comparisons between data generated in experimental cell and animals systems will be contrasted with that obtained from human subjects as often times results differ. Further, the nutritional status is also an important component of the sometimes divergent findings pertaining to the effects of alcohol on the regulation of insulin and glucose metabolism. This work is relevant as the contribution of alcohol intake to the development or exacerbation of type 2 diabetes remains ill-defined and a multi-systems approach is likely needed as both alcohol and diabetes affect multiple targets within the body.

Keywords: alcohol use disorder; ethanol; insulin action; liver; skeletal muscle.

Similar articles

See all similar articles

Cited by 15 articles

See all "Cited by" articles

References

    1. Avogaro A., Tiengo A. Alcohol, glucose metabolism and diabetes. Diabetes Metab. Rev. 1993;9:129–146. doi: 10.1002/dmr.5610090205. - DOI - PubMed
    1. De la Monte S., Derdak Z., Wands J.R. Alcohol, insulin resistance and the liver-brain axis. J. Gastroenterol. Hepatol. 2012;27:S33–S41. doi: 10.1111/j.1440-1746.2011.07023.x. - DOI - PMC - PubMed
    1. Courtney K.E., Polich J. Binge drinking in young adults: Data, definitions, and determinants. Psychol. Bull. 2009;135:142–156. doi: 10.1037/a0014414. - DOI - PMC - PubMed
    1. Esser M.B., Hedden S.L., Kanny D., Brewer R.D., Gfroerer J.C., Naimi T.S. Prevalence of alcohol dependence among us adult drinkers, 2009–2011. Prev. Chronic Dis. 2014;11 doi: 10.5888/pcd11.140329. - DOI - PMC - PubMed
    1. Nutt D.J., King L.A., Phillips L.D. Drug harms in the UK: A multicriteria decision analysis. Lancet. 2010;376:1558–1565. doi: 10.1016/S0140-6736(10)61462-6. - DOI - PubMed

Publication types

Feedback