Tauroursodeoxycholic Acid Protects Retinal Function and Structure in rd1 Mice

Adv Exp Med Biol. 2016;854:431-6. doi: 10.1007/978-3-319-17121-0_57.

Abstract

We explored the potential protective effects of tauroursodeoxycholic acid (TUDCA) on cone photoreceptor survival in a model of rapid retinal degeneration, the ß-Pde6 (rd1) (rd1) mouse model. We injected two strains of rd1 mice (B6.C3-Pde6b (rd1) Hps4(le)/J and C57BL/6J-Pde6b (rd1-2)/J mice) daily from postnatal day (P) 6 to P21 with TUDCA or vehicle. At P21, retinal function was evaluated with light-adapted electroretinography (ERG) and retinal structure was observed with plastic or frozen sections. TUDCA treatment partially preserved function and structure in B6.C3-Pde6b (rd1) Hps4(le)/J mice but only partially preserved structure in C57BL/6J-Pde6b (rd1-2)/J mice. Our results suggest a possible intervention for patients undergoing rapid retinal degeneration.

Keywords: Bile acids; Retinal degeneration; Retinitis pigmentosa; TUDCA; Tauroursodeoxycholic acid; rd1 mice.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Count
  • Disease Models, Animal
  • Electroretinography
  • Humans
  • Mice
  • Mice, Inbred C57BL
  • Mice, Mutant Strains
  • Photoreceptor Cells, Vertebrate / drug effects
  • Photoreceptor Cells, Vertebrate / pathology
  • Protective Agents / administration & dosage
  • Protective Agents / pharmacology*
  • Retina / drug effects*
  • Retina / pathology
  • Retina / physiopathology
  • Retinitis Pigmentosa / pathology
  • Retinitis Pigmentosa / physiopathology
  • Retinitis Pigmentosa / prevention & control*
  • Species Specificity
  • Taurochenodeoxycholic Acid / administration & dosage
  • Taurochenodeoxycholic Acid / pharmacology*

Substances

  • Protective Agents
  • Taurochenodeoxycholic Acid
  • ursodoxicoltaurine