Nutritional Impact of a Gluten-Free Casein-Free Diet in Children with Autism Spectrum Disorder

J Autism Dev Disord. 2016 Feb;46(2):673-84. doi: 10.1007/s10803-015-2582-7.


We compared anthropometric values, nutrient intake, the Healthy Eating Index and food variety in children with autism spectrum disorder (ASD), 20 on a gluten-free casein-free (GFCF) diet and 85 on a regular diet in Valencia (Spain) using 3-days food diaries. Those on the GFCF diet had a lower weight, body mass index, and total energy, pantothenic acid, calcium, phosphorus and sodium intake, but a higher intake of fiber, legumes, and vegetables. Further, the GFCF diet group had a better quality of fat intake, but needed supplementation with vitamin D. Randomized controlled trials are required to explore long-term effects of this diet on anthropometric and nutritional status (the focus of our study), but also behavioral symptoms, in children with ASD.

Keywords: ASD (autism spectrum disorder); Casein-free diet; Gluten-free; Growth; Nutrition.

Publication types

  • Controlled Clinical Trial

MeSH terms

  • Autism Spectrum Disorder / diet therapy*
  • Caseins / administration & dosage
  • Caseins / adverse effects*
  • Child
  • Diet, Gluten-Free / adverse effects*
  • Dietary Supplements
  • Female
  • Humans
  • Male
  • Nutritional Status*


  • Caseins