Kaposi Sarcoma-associated Herpesvirus: mechanisms of oncogenesis

Curr Opin Virol. 2015 Oct;14:116-28. doi: 10.1016/j.coviro.2015.08.016. Epub 2015 Sep 29.

Abstract

Kaposi Sarcoma-associated Herpesvirus (KSHV, HHV8) causes three human malignancies, Kaposi Sarcoma (KS), an endothelial tumor, as well as Primary Effusion Lymphoma (PEL) and the plasma cell variant of Multicentric Castleman's Disease (MCD), two B-cell lymphoproliferative diseases. All three cancers occur primarily in the context of immune deficiency and/or HIV infection, but their pathogenesis differs. KS most likely results from the combined effects of an endotheliotropic virus with angiogenic properties and inflammatory stimuli and thus represents an interesting example of a cancer that arises in an inflammatory context. Viral and cellular angiogenic and inflammatory factors also play an important role in the pathogenesis of MCD. In contrast, PEL represents an autonomously growing malignancy that is, however, still dependent on the continuous presence of KSHV and the action of several KSHV proteins.

Publication types

  • Review

MeSH terms

  • Carcinogenesis*
  • Castleman Disease / pathology*
  • Castleman Disease / virology
  • Herpesvirus 8, Human / physiology*
  • Host-Pathogen Interactions*
  • Humans
  • Lymphoma, Primary Effusion / pathology*
  • Lymphoma, Primary Effusion / virology
  • Sarcoma, Kaposi / pathology*
  • Sarcoma, Kaposi / virology