Therapeutic efficacy of a polysaccharide isolated from Cordyceps sinensis on hypertensive rats

Int J Biol Macromol. 2016 Jan;82:308-14. doi: 10.1016/j.ijbiomac.2015.09.060. Epub 2015 Sep 30.

Abstract

This study was aimed to investigate the antihypertensive effect of a polysaccharide fraction from Cordyceps sinensis on spontaneously hypertensive rats (SHR). The CSP1, one component of Cordyceps sinensis polysaccharides (CSP), was obtained after water extraction, deproteinization, de-colorization and purification with DEAE-cellulose 52. And a more homogeneous component CSP1-2 was obtained using Sepharose CL-6B chromatography. CSP1-2 mainly consisted of mannose, glucose and galactose in a molar ratio of about 2:2:1 and its average molecular weight was approximately 2.70×10(4)Da. Pharmacological tests showed that CSP1, in which the CSP1-2 was its main component, had antihypertensive effect by stimulating the secretion of vasodilator NO, decreasing the level of ET-1, epinephrine, noradrenaline and angiotensin II, inhibiting the increase of transforming growth factor β1 (TGF-β1) and lowering the level of inflammatory mediator of C-reactive protein (CRP). These results suggested that CSP1 may possess high potential in treating hypertension.

Keywords: Cordyceps sinensis; Hypertension; Polysaccharides.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antihypertensive Agents / chemistry*
  • Antihypertensive Agents / isolation & purification
  • Antihypertensive Agents / pharmacology*
  • Biomarkers
  • Blood Pressure / drug effects
  • Cordyceps / chemistry*
  • Fungal Polysaccharides / chemistry*
  • Fungal Polysaccharides / isolation & purification
  • Fungal Polysaccharides / pharmacology*
  • Hypertension / blood
  • Hypertension / drug therapy
  • Hypertension / physiopathology
  • Male
  • Molecular Weight
  • Rats
  • Rats, Inbred SHR
  • Spectroscopy, Fourier Transform Infrared

Substances

  • Antihypertensive Agents
  • Biomarkers
  • Fungal Polysaccharides