Hepatic expression of serum amyloid A1 is induced by traumatic brain injury and modulated by telmisartan

Am J Pathol. 2015 Oct;185(10):2641-52. doi: 10.1016/j.ajpath.2015.06.016.


Traumatic brain injury affects the whole body in addition to the direct impact on the brain. The systemic response to trauma is associated with the hepatic acute-phase response. To further characterize this response, we performed controlled cortical impact injury on male mice and determined the expression of serum amyloid A1 (SAA1), an apolipoprotein, induced at the early stages of the acute-phase response in liver and plasma. After cortical impact injury, induction of SAA1 was detectable in plasma at 6 hours post-injury and in liver at 1 day post-injury, followed by gradual diminution over time. In the liver, cortical impact injury increased neutrophil and macrophage infiltration, apoptosis, and expression of mRNA encoding the chemokines CXCL1 and CXCL10. An increase in angiotensin II AT1 receptor mRNA at 3 days post-injury was also observed. Administration of the AT1 receptor antagonist telmisartan 1 hour post-injury significantly decreased liver SAA1 levels and CXCL10 mRNA expression, but did not affect CXCL1 expression or the number of apoptotic cells or infiltrating leukocytes. To our knowledge, this is the first study to demonstrate that SAA1 is induced in the liver after traumatic brain injury and that telmisartan prevents this response. Elucidating the molecular pathogenesis of the liver after brain injury will assist in understanding the efficacy of therapeutic approaches to brain injury.

Publication types

  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute-Phase Reaction / metabolism
  • Angiotensin II Type 1 Receptor Blockers / pharmacology*
  • Animals
  • Benzimidazoles / pharmacology*
  • Benzoates / pharmacology*
  • Brain Injuries / drug therapy*
  • Brain Injuries / metabolism*
  • Brain Injuries / pathology
  • Chemokine CXCL1 / metabolism
  • Chemokine CXCL10 / metabolism
  • Liver / drug effects*
  • Liver / metabolism
  • Male
  • Mice, Inbred C57BL
  • Neutrophils / metabolism
  • Serum Amyloid A Protein / metabolism*
  • Telmisartan


  • Angiotensin II Type 1 Receptor Blockers
  • Benzimidazoles
  • Benzoates
  • CXCL10 protein, human
  • Chemokine CXCL1
  • Chemokine CXCL10
  • Cxcl1 protein, mouse
  • Cxcl10 protein, mouse
  • Serum Amyloid A Protein
  • Telmisartan