Although an 84-year-old patient did not have any coagulopathy and there was no vascular injury at the time of epidural puncture, epidural hematoma developed late in onset Ossification of the posterior longitudinal ligament of the spine was suspected as a potential cause. The vascular hyperplasia in the epidural space is possible in a case of ossification of the posterior longitudinal ligament of the spine. A careful observation is necessary after the epidural catheter insertion in a patient with ossification of the posterior longitudinal ligament.