Cognitive effects following acute wild blueberry supplementation in 7- to 10-year-old children

Eur J Nutr. 2016 Sep;55(6):2151-62. doi: 10.1007/s00394-015-1029-4. Epub 2015 Oct 5.


Purpose: Previously, anthocyanin-rich blueberry treatments have shown positive effects on cognition in both animals and human adults. However, little research has considered whether these benefits transfer to children. Here we describe an acute time-course and dose-response investigation considering whether these cognitive benefits extend to children.

Methods: Using a double-blind cross-over design, on three occasions children (n = 21; 7-10 years) consumed placebo (vehicle) or blueberry drinks containing 15 or 30 g freeze-dried wild blueberry (WBB) powder. A cognitive battery including tests of verbal memory, word recognition, response interference, response inhibition and levels of processing was performed at baseline, and 1.15, 3 and 6 h following treatment.

Results: Significant WBB-related improvements included final immediate recall at 1.15 h, delayed word recognition sustained over each period, and accuracy on cognitively demanding incongruent trials in the interference task at 3 h. Importantly, across all measures, cognitive performance improved, consistent with a dose-response model, with the best performance following 30 g WBB and the worst following vehicle.

Conclusion: Findings demonstrate WBB-related cognitive improvements in 7- to 10-year-old children. These effects would seem to be particularly sensitive to the cognitive demand of task.

Keywords: Anthocyanin; Children; Cognition; Executive function; Flavonoid; Memory.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Blueberry Plants / chemistry*
  • Child
  • Cognition / drug effects*
  • Cross-Over Studies
  • Diet
  • Dietary Supplements
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Female
  • Flavonoids / administration & dosage
  • Flavonoids / analysis
  • Freeze Drying
  • Fruit / chemistry*
  • Humans
  • Male
  • Memory / drug effects
  • Plant Preparations / chemistry
  • Plant Preparations / pharmacology*
  • Powders / chemistry
  • Treatment Outcome


  • Flavonoids
  • Plant Preparations
  • Powders