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Review
. 2015;10(10):1553-78.
doi: 10.2217/fmb.15.90. Epub 2015 Oct 6.

Clinical Development of RTS,S/AS Malaria Vaccine: A Systematic Review of Clinical Phase I-III Trials

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Review

Clinical Development of RTS,S/AS Malaria Vaccine: A Systematic Review of Clinical Phase I-III Trials

Selidji T Agnandji et al. Future Microbiol. .

Abstract

The first clinical Phase III trial evaluating a malaria vaccine was completed in December 2013 at 11 sites from seven sub-Saharan African countries. This systematic review assesses data of Phase I-III trials including malaria-naive adults and adults, children and infants from malaria endemic settings in sub-Saharan Africa. The main endpoint of this systematic review was an analysis of the consistency of efficacy and immunogenicity data from respective Phase I-III trials. In addition, safety data from a pooled analysis of RTS/AS Phase II trials and RTS,S/AS01 Phase III trial were reviewed. The RTS,S/AS01 malaria vaccine may become available on the market in the coming year. If so, further strategies should address challenges on how to optimize vaccine efficacy and implementation of RTS,S/AS01 vaccine within the framework of established malaria control measures.

Keywords: AS01; AS02; RTS,S/AS; anti-CSP; anti-HBs; geometric mean concentration; immune responses; vaccine efficacy.

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