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Review
, 3 (10), 1115-22

T-cell-based Immunotherapy: Adoptive Cell Transfer and Checkpoint Inhibition

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Review

T-cell-based Immunotherapy: Adoptive Cell Transfer and Checkpoint Inhibition

Roch Houot et al. Cancer Immunol Res.

Abstract

Tumor immunotherapy has had demonstrable efficacy in patients with cancer. The most promising results have been with T-cell-based therapies. These include adoptive cell transfer of tumor-infiltrating lymphocytes, genetically engineered T cells, and immune checkpoint inhibitor antibodies. In this review, we describe the different T-cell-based strategies currently in clinical trials and put their applications, present and future, into perspective.

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