Drug Reaction, Eosinophilia and Systemic Symptoms (DRESS) syndrome secondary to allopurinol with early lymphadenopathy and symptom relapse

BMJ Case Rep. 2015 Oct 5:2015:bcr2015211222. doi: 10.1136/bcr-2015-211222.

Abstract

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare condition with a mortality rate of up to 10%. Herein, we describe a case of DRESS syndrome secondary to allopurinol and which may have been precipitated by amoxicillin, the diagnostic challenge it represented and the successful treatment of the condition with corticosteroids.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Cortex Hormones / administration & dosage*
  • Aged
  • Allopurinol / adverse effects*
  • Amoxicillin / adverse effects*
  • Drug Hypersensitivity Syndrome / diagnosis*
  • Drug Hypersensitivity Syndrome / drug therapy*
  • Eosinophils / drug effects*
  • Female
  • Fever
  • Humans
  • Leukocyte Count
  • Recurrence

Substances

  • Adrenal Cortex Hormones
  • Allopurinol
  • Amoxicillin