From bench to patient: model systems in drug discovery

Dis Model Mech. 2015 Oct 1;8(10):1171-4. doi: 10.1242/dmm.023036.


Model systems, including laboratory animals, microorganisms, and cell- and tissue-based systems, are central to the discovery and development of new and better drugs for the treatment of human disease. In this issue, Disease Models & Mechanisms launches a Special Collection that illustrates the contribution of model systems to drug discovery and optimisation across multiple disease areas. This collection includes reviews, Editorials, interviews with leading scientists with a foot in both academia and industry, and original research articles reporting new and important insights into disease therapeutics. This Editorial provides a summary of the collection's current contents, highlighting the impact of multiple model systems in moving new discoveries from the laboratory bench to the patients' bedsides.

Publication types

  • Editorial
  • Introductory Journal Article

MeSH terms

  • Animals
  • Disease Models, Animal
  • Drug Discovery*
  • Genetic Engineering
  • Humans
  • Mice
  • Models, Biological*
  • Translational Research, Biomedical*
  • Zebrafish