Immunohistologic findings and results of treatment with cyclosporine in ligneous conjunctivitis

Am J Ophthalmol. 1989 Feb 15;107(2):160-6. doi: 10.1016/0002-9394(89)90216-x.


Using immunohistochemical techniques, we studied ligneous conjunctival lesions from two patients. A significant immune reaction was detected that was characterized by activated T lymphocytes and focal accumulation of plasma cells and B lymphocytes. Immunofluorescent studies demonstrated that IgG was a prominent component of the amorphous hyaline material seen in these lesions. After previous treatment methods had failed, both patients were treated with excisional biopsy and topical cyclosporine. Patient 1 had a dramatic response, with complete resolution of the lesions. Patient 2 had a significant improvement resulting in small, slow-growing recurrences instead of the rapid and extensive recurrences that occurred before treatment with cyclosporine.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Child, Preschool
  • Conjunctiva / pathology
  • Conjunctivitis / drug therapy*
  • Conjunctivitis / metabolism
  • Conjunctivitis / pathology
  • Cyclosporins / therapeutic use*
  • Female
  • Fluorescent Antibody Technique
  • Humans
  • Lymphocytes / classification
  • Lymphocytes / pathology


  • Cyclosporins