H2S: A Novel Gasotransmitter that Signals by Sulfhydration

Trends Biochem Sci. 2015 Nov;40(11):687-700. doi: 10.1016/j.tibs.2015.08.007. Epub 2015 Oct 1.


Hydrogen sulfide (H2S) is a member of the growing family of gasotransmitters. Once regarded as a noxious molecule predominantly present in the atmosphere, H2S is now known to be synthesized endogenously in mammals. H2S participates in a myriad of physiological processes ranging from regulation of blood pressure to neuroprotection. Its chemical nature precludes H2S from being stored in vesicles and acting on receptor proteins in the fashion of other chemical messengers. Thus, novel cellular mechanisms have evolved to mediate its effects. This review focuses on sulfhydration (or persulfidation), which appears to be the principal post-translational modification elicited by H2S.

Keywords: cysteine; gasotransmitter; hydrogen sulfide; sulfhydration.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Gasotransmitters / metabolism*
  • Hydrogen Sulfide / metabolism*
  • Signal Transduction


  • Gasotransmitters
  • Hydrogen Sulfide