Secukinumab distributes into dermal interstitial fluid of psoriasis patients as demonstrated by open flow microperfusion

Exp Dermatol. 2016 Feb;25(2):157-9. doi: 10.1111/exd.12863. Epub 2015 Nov 23.
No abstract available

Keywords: dermal open flow microperfusion; monoclonal antibody; pharmacokinetics; psoriasis; secukinumab.

Publication types

  • Comparative Study
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Monoclonal / administration & dosage
  • Antibodies, Monoclonal / immunology
  • Antibodies, Monoclonal / pharmacokinetics*
  • Antibodies, Monoclonal, Humanized
  • Body Fluids / metabolism*
  • Body Weight
  • Drug Evaluation, Preclinical
  • Humans
  • Injections, Subcutaneous
  • Interleukin-17 / immunology
  • Perfusion
  • Psoriasis / metabolism*
  • Time Factors

Substances

  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Humanized
  • IL17A protein, human
  • Interleukin-17
  • secukinumab