Emerging roles of the Th17/IL-17-axis in glomerulonephritis

Cytokine. 2016 Jan:77:238-44. doi: 10.1016/j.cyto.2015.07.029. Epub 2015 Oct 2.

Abstract

Different T cell subsets have been implicated in the pathogenesis of glomerulonephritis. Several lines of evidence indicate the recently identified interleukin-17 (IL-17)-producing T cells (Th17 cells) to be involved in the renal inflammatory cascade associated with glomerulonephritis. In this review we outline different forms of glomerulonephritis and the contribution of the Th17/IL-17-axis in mediating the downstream effects and pathology associated with the disease. Learning more about the Th17/IL-17-axis can help to develop promising therapeutic strategy for the treatment of various forms of glomerulonephritis.

Keywords: Glomerulonephritis; IL-17; T-helper 17.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Glomerulonephritis / immunology*
  • Glomerulonephritis / metabolism
  • Humans
  • Inflammation Mediators / immunology
  • Inflammation Mediators / metabolism
  • Interleukin-17 / immunology*
  • Interleukin-17 / metabolism
  • Kidney / immunology
  • Kidney / metabolism
  • Kidney / pathology
  • Models, Immunological
  • Receptors, Interleukin-17 / immunology
  • Receptors, Interleukin-17 / metabolism
  • Signal Transduction / immunology*
  • Th17 Cells / immunology*
  • Th17 Cells / metabolism

Substances

  • IL17A protein, human
  • Inflammation Mediators
  • Interleukin-17
  • Receptors, Interleukin-17