Constitutive mutants in the yeast pheromone response: ordered function of the gene products

Cell. 1989 Feb 10;56(3):479-86. doi: 10.1016/0092-8674(89)90250-x.


The alpha factor pheromone inhibits the division of yeast a cells. A general method was developed for isolating mutants that exhibit constitutive activation of the pheromone response pathway. A dominant allele of the STE4 locus was recovered in addition to recessive mutations in the SCG1 gene. SCG1 and STE4 are known to encode G alpha and G beta homologs, respectively. Analysis of double mutants suggests that the STE4 gene product functions after the SCG1 product but before the STE5 product.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Crosses, Genetic
  • Genes*
  • Genes, Dominant
  • Genes, Fungal*
  • Genes, Recessive
  • Genotype
  • Mating Factor
  • Mutation*
  • Peptides / genetics*
  • Peptides / physiology
  • Phenotype
  • Pheromones / genetics*
  • Saccharomyces cerevisiae / genetics*
  • Saccharomyces cerevisiae / physiology


  • Peptides
  • Pheromones
  • Mating Factor