Viral hepatitis: A new HCV cell culture model for the next clinical challenges

Nat Rev Gastroenterol Hepatol. 2015 Nov;12(11):611-3. doi: 10.1038/nrgastro.2015.170. Epub 2015 Oct 6.

Abstract

Despite advances in hepatitis C treatment, substantial clinical hurdles remain to achieve universal cure and global control of infection. Saeed et al. identified SEC14L2 as a host factor permitting replication of clinical HCV isolates in cell culture, providing a novel system to model infection of patient-derived viruses.

Publication types

  • News
  • Comment

MeSH terms

  • Carcinoma, Hepatocellular / metabolism*
  • Carcinoma, Hepatocellular / virology*
  • Carrier Proteins / metabolism*
  • Cell Culture Techniques*
  • Genotype*
  • Hepacivirus / genetics*
  • Hepacivirus / growth & development*
  • Host-Derived Cellular Factors / metabolism*
  • Humans
  • Lipoproteins / metabolism*
  • Trans-Activators / metabolism*
  • Virus Replication*

Substances

  • Carrier Proteins
  • Host-Derived Cellular Factors
  • Lipoproteins
  • Trans-Activators