Transcriptional Enhancers in the Regulation of T Cell Differentiation

Front Immunol. 2015 Sep 9;6:462. doi: 10.3389/fimmu.2015.00462. eCollection 2015.

Abstract

The changes in phenotype and function that characterize the differentiation of naïve T cells to effector and memory states are underscored by large-scale, coordinated, and stable changes in gene expression. In turn, these changes are choreographed by the interplay between transcription factors and epigenetic regulators that act to restructure the genome, ultimately ensuring lineage-appropriate gene expression. Here, we focus on the mechanisms that control T cell differentiation, with a particular focus on the role of regulatory elements encoded within the genome, known as transcriptional enhancers (TEs). We discuss the central role of TEs in regulating T cell differentiation, both in health and disease.

Keywords: T cell differentiation; differentiation; epigenetics; transcription factors; transcriptional enhancers.

Publication types

  • Review