Making Biological Sense of GWAS Data: Lessons from the FTO Locus

Cell Metab. 2015 Oct 6;22(4):538-9. doi: 10.1016/j.cmet.2015.09.018.

Abstract

GWAS have yielded many candidate loci for complex diseases like obesity, but interpreting the biological context of these findings has been difficult. Claussnitzer et al. (2015) use a sophisticated combination of bioinformatic and experimental approaches to address this bottleneck for variants in the FTO locus that associate with obesity.

Publication types

  • Comment

MeSH terms

  • Adipocytes / metabolism*
  • Animals
  • Humans
  • Obesity / genetics*
  • Proteins / genetics*
  • Thermogenesis / genetics*

Substances

  • Proteins