ACE inhibitors and diuretics. The benefits of combined therapy for hypertension

Postgrad Med. 1989 Feb 15;85(3):127-32, 137-9. doi: 10.1080/00325481.1989.11700602.


Hypertension and its consequences continue to threaten the health of as many as 60 million Americans. Effective control of blood pressure can be achieved in some patients with a single agent and in many of the remainder with combination therapy. The ideal combination regimen is one that is at least as effective as a single agent, has minimal or no side effects, has a wide therapeutic index, is simple to administer, and is effective in a wide variety of patient populations. When used in combination, the thiazide diuretics and the angiotensin-converting enzyme inhibitors have been shown to improve blood pressure reduction over either drug used alone. In addition, the combination is effective in a wide range of patient populations (blacks and whites, young and old) and is accompanied by fewer adverse metabolic effects than the thiazides alone. Finally, the combination has a more positive impact on quality of life than other combinations involving the thiazide diuretics.

Publication types

  • Review

MeSH terms

  • Aged
  • Angiotensin-Converting Enzyme Inhibitors / administration & dosage*
  • Benzothiadiazines*
  • Diuretics
  • Drug Therapy, Combination
  • Humans
  • Hypertension / drug therapy*
  • Patient Compliance
  • Quality of Life
  • Sodium Chloride Symporter Inhibitors / administration & dosage*


  • Angiotensin-Converting Enzyme Inhibitors
  • Benzothiadiazines
  • Diuretics
  • Sodium Chloride Symporter Inhibitors