Clinical safety of aspartame

Am Fam Physician. 1989 Feb;39(2):201-6.


Aspartame is a synthetic sweetener commonly used in soft drinks and many foods. Even with high doses, the metabolites of this sweetener do not accumulate in toxic amounts. To date, no definite symptom complex has been connected with aspartame, and it is considered safe for use in all populations, including diabetics, phenylketonuric heterozygotes and pregnant women.

Publication types

  • Review

MeSH terms

  • Aspartame* / administration & dosage
  • Aspartame* / adverse effects
  • Aspartame* / metabolism
  • Dipeptides* / administration & dosage
  • Dipeptides* / adverse effects
  • Dipeptides* / metabolism
  • Humans


  • Dipeptides
  • Aspartame