Sleep Apnea Research in Animals. Past, Present, and Future

Am J Respir Cell Mol Biol. 2016 Mar;54(3):299-305. doi: 10.1165/rcmb.2015-0218TR.


Obstructive sleep apnea (OSA) is a common disorder that describes recurrent collapse of the upper airway during sleep. Animal models have been pivotal to the understanding of OSA pathogenesis, consequences, and treatment. In this review, we highlight the history of OSA research in animals and include the discovery of animals with spontaneous OSA, the induction of OSA in animals, and the emulation of OSA using exposures to intermittent hypoxia and sleep fragmentation.

Keywords: animal; fragmentation; intermittent hypoxia; sleep apnea.

Publication types

  • Historical Article
  • Review

MeSH terms

  • Animals
  • Biomedical Research* / history
  • Biomedical Research* / trends
  • Diffusion of Innovation
  • Disease Models, Animal
  • Forecasting
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Hypoxia / complications
  • Hypoxia / physiopathology
  • Lung / physiopathology*
  • Prognosis
  • Respiration*
  • Sleep Apnea Syndromes / diagnosis
  • Sleep Apnea Syndromes / etiology
  • Sleep Apnea Syndromes / history
  • Sleep Apnea Syndromes / physiopathology*
  • Sleep Apnea Syndromes / therapy
  • Sleep*
  • Species Specificity