[Successful combination treatment for psoriasis with phototherapy and low-dose cytokines: A spontaneous, retrospective observational clinical study]

Hautarzt. 2015 Nov;66(11):849-54. doi: 10.1007/s00105-015-3698-6.
[Article in German]

Abstract

Background: Psoriasis is a chronic, inflammatory autoimmune skin disease that affects 1-3% of the world's population. Most patients with psoriasis have plaque psoriasis or psoriasis vulgaris, characterized by thickened erythematous scaly plaques and presenting in a variety of forms with distinct characteristics. Psoriasis is associated with a decreased quality of life as well as with severe comorbidities.

Objectives: The aim of this spontaneous, retrospective observational clinical study was to evaluate the pharmacological activity of advanced treatment based on the use of UVA-1 laser therapy with or without the co-administration of low dose cytokines [interleukin (IL)-4, IL-10] and anti-IL-1 antibodies in patients affected by psoriasis vulgaris.

Results: In this study the efficacy of UVA-1 phototherapy and, in parallel, the decisive (statistically relevant) boosting activity of low-dose cytokines in ameliorating the Psoriasis Area Severity Index (PASI) score were assessed. These results show the effectiveness of combined use of phototherapy and low-dose cytokines therapy, highlighting the fundamental role of anti-inflammatory cytokines (IL-4, IL-10, anti-IL-1 antibodies) in the treatment of psoriasis vulgaris.

Conclusion: Further studies are necessary to confirm these preliminary data.

Keywords: Anti-IL-1 antibody; Interleukin-10; Interleukin-4; Plaque psoriasis; Psoriasis vulgaris.

Publication types

  • English Abstract
  • Observational Study

MeSH terms

  • Adult
  • Combined Modality Therapy / methods
  • Cytokines / administration & dosage*
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Immunologic Factors / administration & dosage
  • Immunotherapy / methods
  • Male
  • Middle Aged
  • PUVA Therapy / methods*
  • Pilot Projects
  • Psoriasis / drug therapy*
  • Psoriasis / pathology*
  • Radiation-Sensitizing Agents / administration & dosage*
  • Treatment Outcome

Substances

  • Cytokines
  • Immunologic Factors
  • Radiation-Sensitizing Agents