Do count-based differential expression methods perform poorly when genes are expressed in only one condition?

Genome Biol. 2015 Oct 8:16:222. doi: 10.1186/s13059-015-0781-3.


A response to 'Comprehensive evaluation of differential gene expression analysis methods for RNA-seq data' by Rapaport F, Khanin R, Liang Y, Pirun M, Krek A, Zumbo P, Mason CE, Socci ND and Betel D in Genome Biology, 2013, 14:R95.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • High-Throughput Nucleotide Sequencing / statistics & numerical data*
  • Humans
  • Nerve Tissue Proteins / genetics*
  • RNA / genetics*
  • Sequence Analysis, RNA / statistics & numerical data*
  • Software*


  • Nerve Tissue Proteins
  • RNA