Evaluation of turmeric (Curcuma longa) effect on biochemical and pathological parameters of liver and kidney in chicken aflatoxicosis

Pharm Biol. 2016;54(5):780-7. doi: 10.3109/13880209.2015.1080731. Epub 2015 Oct 9.

Abstract

Context: Aflatoxins as potent mycotoxins can influence vital parameters in chickens. Turmeric was used in decreasing toxic effect of mycotoxins on vital organs, traditionally.

Objective: The study compared the protective effect of turmeric and Mycoad(TR) in broilers exposed to aflatoxin.

Materials and methods: Chickens (270) were divided into six groups. The chickens were fed a basal diet, turmeric extract (5 mg/kg diet), Mycoad(TR) (25 mg/kg diet), productive aflatoxin (3 mg/kg diet), aflatoxin plus turmeric extract (3 versus 5 mg/kg diet), and aflatoxin plus Mycoad(TR) (3 versus 25 mg/kg diet) in basal diet. At 28 d old, we determined plasma concentration of total protein, albumin, triglyceride, cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), calcium, potassium, phosphorous, uric acid, aspartate transferase (AST), and alanine aminotransferase (ALT). Furthermore, liver and kidney were sampled for pathological examination.

Results: Chickens fed turmeric with aflatoxin had significant lower ALT, AST, and uric acid than chickens fed aflatoxin (11.4 ± 0.79, 228 ± 9, and 6 ± 0.4 versus 17.2 ± 1.7, 283 ± 5, and 7.7 ± 0.1) whereas, total protein, calcium, and HDL values in chickens fed aflatoxin plus turmeric increased significantly (2.66 ± 0.16, 8.4 ± 0.2, and 920 ± 4.1 versus 1.7 ± 0.17, 7 ± 0.2, and 690 ± 4.8). Pathological examination revealed severe congestion, degeneration, and necrosis in liver and kidney in chickens that received aflatoxin.

Discussion and conclusion: The study showed that turmeric may provide protection against the toxic effects of aflatoxin on liver and kidney.

Keywords: Clinical biochemistry; herbal plant; toxicity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aflatoxins / toxicity*
  • Animal Feed*
  • Animals
  • Chickens
  • Curcuma*
  • Drug Evaluation, Preclinical / methods
  • Kidney / chemistry
  • Kidney / drug effects*
  • Kidney / pathology
  • Liver / chemistry
  • Liver / drug effects*
  • Liver / pathology
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Poultry Diseases / chemically induced
  • Poultry Diseases / drug therapy
  • Poultry Diseases / pathology

Substances

  • Aflatoxins
  • Plant Extracts
  • turmeric extract