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, 16 (11), 1421-6

No Time to Waste--The Ethical Challenges Created by CRISPR: CRISPR/Cas, Being an Efficient, Simple, and Cheap Technology to Edit the Genome of Any Organism, Raises Many Ethical and Regulatory Issues Beyond the Use to Manipulate Human Germ Line Cells

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No Time to Waste--The Ethical Challenges Created by CRISPR: CRISPR/Cas, Being an Efficient, Simple, and Cheap Technology to Edit the Genome of Any Organism, Raises Many Ethical and Regulatory Issues Beyond the Use to Manipulate Human Germ Line Cells

Arthur L Caplan et al. EMBO Rep.

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Figure 1
Figure 1. Gene drives can be used to alter population-wide traits
A gene drive is preferentially inherited by all offspring and would quickly spread itself in the target population. The endonuclease cuts the homologous wild-type chromosome; repairing the break using homologous recombination therefore copies the gene drive onto the wild-type chromosome. Gene-drive technology could be used to eradicate diseases, such as malaria or dengue fever, by targeting wild populations of disease-transmitting mosquitoes but could have unanticipated secondary effects on other species. Figure adapted from .

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