The reason sickle reticulocytes expose PS

Blood. 2015 Oct 8;126(15):1737-8. doi: 10.1182/blood-2015-08-665117.

Abstract

In this issue of Blood, Mankelow et al link phosphatidylserine (PS) exposure in sickle erythrocytes to a physiological event in reticulocyte maturation. This discovery has implications for efforts to prevent thrombosis in sickle cell disease (SCD).

Publication types

  • Comment

MeSH terms

  • Anemia, Sickle Cell / blood*
  • Anemia, Sickle Cell / pathology*
  • Autophagy*
  • Erythrocytes / pathology*
  • Humans
  • Phosphatidylserines / metabolism*
  • Reticulocytes / pathology*

Substances

  • Phosphatidylserines