The Neuropilins (Nrps) are a family of essential cell surface receptors involved in multiple fundamental cellular signaling cascades. Nrp family members have key functions in VEGF-dependent angiogenesis and semaphorin-dependent axon guidance, controlling signaling and cross-talk between these fundamental physiological processes. More recently, Nrp function has been found in diverse signaling and adhesive functions, emphasizing their role as pleiotropic co-receptors. Pathological Nrp function has been shown to be important in aberrant activation of both canonical and alternative pathways. Here we review key recent insights into Nrp function in human health and disease.
Keywords: VEGFR; angiogenesis; heparin-binding protein; neuropilin; protein-protein interaction; receptor structure-function; semaphorin; vascular endothelial growth factor (VEGF).
© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.