Toward a rational design of combination therapy in cancer

Oncoimmunology. 2015 Jul 7;4(11):e1046674. doi: 10.1080/2162402X.2015.1046674. eCollection 2015 Nov.


By merging computational systems modeling and experimental approaches, we have uncovered treatments reprogramming pro-angiogenic monocytes present in breast tumor into immunologically potent cells capable of mediating an anti-tumor immune response. The unraveled pathways and ligands which underlie monocyte pro-angiogenic activity have a strong predictive value for breast cancer patient relapse - free survival.

Keywords: angiogenesis, monocytes, immune suppression, breast cancer, modeling.