Synthesis of Some Benzimidazole Derivatives Bearing 1,3,4-Oxadiazole Moiety as Anticancer Agents

Bereket Mochona; Elizabeth Mazzio; Madhavei Gangapurum; Nelly Mateeva; K K Redda

doi:10.7598/cst2015.1029

Synthesis of Some Benzimidazole Derivatives Bearing 1,3,4-Oxadiazole Moiety as Anticancer Agents

Chem Sci Trans. 2015 Apr;4(2):534-540. doi: 10.7598/cst2015.1029.

Authors

Bereket Mochona¹, Elizabeth Mazzio², Madhavei Gangapurum², Nelly Mateeva¹, K K Redda²

Affiliations

¹ College of Science and Technology, Department of Chemistry, Florida A&M University, Tallahassee, FL 32307, USA.
² College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL 32307, USA.

Abstract

In an effort to establish new benzimidazole related structural leads with improved anticancer activity, several new benzimidazole derivatives (5a-i) with 1,3,4-oxadiazole scaffold incorporated were synthesized and studied for their anticancer activity. The anticancer screening against MDA-MB-231 breast cancer cell lines showed that compound (5c) exhibited moderate cytotoxicity.

Keywords: 1, 3, 4-Oxadizole; Benzimidazole; Cytotoxcity; Pharmacophore hybridization.

Abstract

Grant support