A Community Outbreak of Group A Beta Haemolytic Streptococci With Transferable Resistance to Erythromycin

Epidemiol Infect. 1989 Feb;102(1):85-91. doi: 10.1017/s095026880002971x.

Abstract

Erythromycin resistance amongst group A streptococci (GAS) in Great Britain is a relatively rare occurrence and outbreaks have been sporadically reported. Over an 8-month period in 1986 ten associated cases occurred in the town of Bridgewater in Somerset. Isolates were group A, type M4 and resistant to erythromycin (MIC 8 mg/l) but sensitive to lincomycin and clindamycin. Erythromycin resistance was transferable from all isolates to a group A recipient strain. No plasmid DNA could be detected in the original isolates or transconjugants.

MeSH terms

  • Adult
  • Child
  • Child, Preschool
  • Conjugation, Genetic
  • Disease Outbreaks*
  • Drug Resistance, Microbial / genetics
  • England
  • Erythromycin / pharmacology*
  • Female
  • Humans
  • Infant
  • Male
  • Schools
  • Streptococcal Infections / epidemiology*
  • Streptococcal Infections / microbiology
  • Streptococcus pyogenes / genetics
  • Streptococcus pyogenes / isolation & purification

Substances

  • Erythromycin