Effects of a ketogenic diet on auditory gating in DBA/2 mice: A proof-of-concept study

Schizophr Res. 2015 Dec;169(1-3):351-354. doi: 10.1016/j.schres.2015.09.022. Epub 2015 Oct 9.


Although the ketogenic diet has shown promise in a pilot study and case report in schizophrenia, its effects in animal models of hypothesized disease mechanisms are unknown. This study examined effects of treatment with the ketogenic diet on hippocampal P20/N40 gating in DBA/2 mice, a translational endophenotype that mirrors inhibitory deficits in P50 sensory gating in schizophrenia patients. As expected, the diet increased blood ketone levels. Animals with the highest ketone levels showed the lowest P20/N40 gating ratios. These preliminary results suggest that the ketogenic diet may effectively target sensory gating deficits and is a promising area for additional research in schizophrenia.

Keywords: Gating; Hippocampus; Ketogenic diet; P50; Schizophrenia.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Acoustic Stimulation
  • Analysis of Variance
  • Animals
  • Diet, Ketogenic*
  • Dose-Response Relationship, Drug
  • Electroencephalography
  • Evoked Potentials, Auditory / drug effects*
  • Evoked Potentials, Auditory / physiology
  • Hippocampus / drug effects
  • Hippocampus / physiology
  • Ketones / blood
  • Male
  • Mice
  • Neural Inhibition / drug effects
  • Patch-Clamp Techniques
  • Sensory Gating / drug effects*
  • Sensory Gating / physiology


  • Ketones