Neuronal control of bone and muscle

Bone. 2015 Nov:80:95-100. doi: 10.1016/j.bone.2015.05.006.

Abstract

The functional interplay between bone and muscle that enables locomotion is a fundamental aspect of daily life. However, other interactions between bone and muscle continue to attract attention as our understanding of the breath and importance of this inter-relationship continues to expand. Of particular interest is the regulatory connection between bone and muscle, which adds a new insight to the coordination of the bone/muscle unit. We have appreciated the importance of neuronal signaling to the control of bone turnover and muscle contraction, but recent data indicate that neuronal inputs control a far wider range of bone and muscle physiology than previously appreciated. This review outlines the role of the sympathetic nervous system and neuronal/neuropeptide inputs upon the regulation of bone and muscle tissue, and the potential for co-regulatory actions, particularly involving the sympathetic nervous system. This article is part of a Special Issue entitled "Muscle Bone Interactions".

Keywords: Hypothalamus; Leptin; Myocyte; Neuropeptide Y; Osteoblast; Sympathetic nervous system.

Publication types

  • Review

MeSH terms

  • Animals
  • Bone and Bones
  • Humans
  • Hypothalamus / cytology*
  • Hypothalamus / metabolism
  • Leptin / metabolism
  • Muscle Cells / cytology
  • Muscle Cells / metabolism
  • Neurons / cytology*
  • Neurons / physiology
  • Neuropeptide Y / metabolism

Substances

  • Leptin
  • Neuropeptide Y