Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Nov 3;608:51-6.
doi: 10.1016/j.neulet.2015.10.012. Epub 2015 Oct 28.

Activation of Synaptic and Extrasynaptic Glycine Receptors by Taurine in Preoptic Hypothalamic Neurons

Affiliations

Activation of Synaptic and Extrasynaptic Glycine Receptors by Taurine in Preoptic Hypothalamic Neurons

Janardhan Prasad Bhattarai et al. Neurosci Lett. .

Abstract

Taurine is an essential amino-sulfonic acid having a fundamental function in the brain, participating in both cell volume regulation and neurotransmission. Using a whole cell voltage patch clamp technique, the taurine-activated neurotransmitter receptors in the preoptic hypothalamic area (PHA) neurons were investigated. In the first set of experiments, different concentrations of taurine were applied on PHA neurons. Taurine-induced responses were concentration-dependent. Taurine-induced currents were action potential-independent and sensitive to strychnine, suggesting the involvement of glycine receptors. In addition, taurine activated not only α-homomeric, but also αβ-heteromeric glycine receptors in PHA neurons. Interestingly, a low concentration of taurine (0.5mM) activated glycine receptors, whereas a higher concentration (3mM) activated both glycine and gamma-aminobutyric acid A (GABAA) receptors in PHA neurons. These results suggest that PHA neurons are influenced by taurine and respond via glycine and GABAA receptors.

Keywords: -Heteromeric; -Homomeric; GABA receptors; Glycine receptors; Preoptic hypothalamic neurons; Taurine; α; αβ.

Similar articles

See all similar articles

Cited by 3 articles

Publication types

MeSH terms

LinkOut - more resources

Feedback