Recent advances in direct cardiac reprogramming

Curr Opin Genet Dev. 2015 Oct;34:77-81. doi: 10.1016/j.gde.2015.09.004. Epub 2015 Oct 24.


Human adult cardiomyocytes have limited regenerative capacity resulting in permanent loss of cardiomyocytes in the setting of many forms of heart disease. In an effort to replace lost cells, several groups have reported successful reprogramming of fibroblasts into induced cardiomyocyte-like cells (iCMs) without going through an intermediate progenitor or stem cell stage in murine and human models. This direct cardiac reprogramming approach holds promise as a potential method for regenerative medicine in the future and for dissecting the regulatory control of cell fate determination. Here we review the recent advances in the direct cardiac reprogramming field and the challenges that must be overcome to move this strategy closer to clinical application.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Animals
  • Cell Differentiation / genetics*
  • Cellular Reprogramming / genetics*
  • Fibroblasts / cytology
  • Fibroblasts / metabolism
  • Heart Diseases / genetics*
  • Heart Diseases / therapy
  • Humans
  • Mice
  • Myocardium / metabolism
  • Myocardium / pathology
  • Myocytes, Cardiac / cytology*
  • Myocytes, Cardiac / transplantation
  • Regeneration / genetics