Common Variable Immunodeficiency: Diagnosis, Management, and Treatment

Immunol Allergy Clin North Am. 2015 Nov;35(4):637-58. doi: 10.1016/j.iac.2015.07.009. Epub 2015 Sep 4.


Common variable immunodeficiency (CVID) refers to a grouping of antibody deficiencies that lack a more specific genetic or phenotypic classification. It is the immunodeficiency classification with the greatest number of constituents, likely because of the numerous ways in which antibody production can be impaired and the frequency in which antibody production becomes impaired in human beings. CVID comprises a heterogeneous group of rare diseases. Consequently, CVID presents a significant challenge for researchers and clinicians. Despite these difficulties, both our understanding of and ability to manage this grouping of complex immune diseases has advanced significantly over the past 60 years.

Keywords: Antibody deficiency; Autoimmunity; CVID; Common variable immunodeficiency; Immune activation; Lymphoproliferation; Primary immune deficiency.

Publication types

  • Review

MeSH terms

  • Common Variable Immunodeficiency / diagnosis*
  • Common Variable Immunodeficiency / etiology
  • Common Variable Immunodeficiency / metabolism
  • Common Variable Immunodeficiency / therapy*
  • Diagnosis, Differential
  • Disease Management
  • Humans