Specific Antibody Deficiencies

Luke A Wall; Victoria R Dimitriades; Ricardo U Sorensen

doi:10.1016/j.iac.2015.07.003

Specific Antibody Deficiencies

Immunol Allergy Clin North Am. 2015 Nov;35(4):659-70. doi: 10.1016/j.iac.2015.07.003. Epub 2015 Aug 25.

Authors

Luke A Wall¹, Victoria R Dimitriades², Ricardo U Sorensen²

Affiliations

¹ Section of Allergy Immunology, Department of Pediatrics, Louisiana State University Health Sciences Center, Jeffrey Modell Center for Primary Immunodeficiencies, 200 Henry Clay Avenue, New Orleans, LA 70118, USA. Electronic address: lwall@lsuhsc.edu.
² Section of Allergy Immunology, Department of Pediatrics, Louisiana State University Health Sciences Center, Jeffrey Modell Center for Primary Immunodeficiencies, 200 Henry Clay Avenue, New Orleans, LA 70118, USA.

PMID: 26454312
DOI: 10.1016/j.iac.2015.07.003

Abstract

Patients with specific antibody deficiency (SAD) have a deficient immunologic response to polysaccharide antigens. Such patients experience sinopulmonary infections with increased frequency, duration, or severity compared with the general population. SAD is definitively diagnosed by immunologic challenge with a pure polysaccharide vaccine in patients 2 years old and older who have otherwise intact immunity, using the 23-valent pneumococcal polysaccharide vaccine as the current gold standard. Specific antibody deficiencies comprise multiple immunologic phenotypes. Treatment must be tailored based on the severity of symptoms. Most patients have a good prognosis. The deficiency may resolve over time, especially in children.

Keywords: Immunoglobulin replacement; Pneumococcal polysaccharide vaccine; Recurrent sinopulmonary infections; Specific antibody deficiency; Vaccine failure.

Publication types

Review

MeSH terms

Diagnosis, Differential
Disease Management
Dysgammaglobulinemia / diagnosis*
Dysgammaglobulinemia / epidemiology
Dysgammaglobulinemia / etiology
Dysgammaglobulinemia / therapy*
Humans
Prognosis