Primary Immunodeficiency Masquerading as Allergic Disease

Immunol Allergy Clin North Am. 2015 Nov;35(4):767-78. doi: 10.1016/j.iac.2015.07.008. Epub 2015 Sep 4.


Primary immune deficiencies (PIDs) are an uncommon heterogeneous group of diseases that result from fundamental defects in the proteins and cells that enable specific immune responses. Common allergic reactions (eczema, allergic rhinitis, asthma, and food allergies) are exaggerated immune responses that may be manifestations of an underlying PID. Early diagnosis and treatment has significant bearing on outcome. Immune suppression with systemic corticosteroids in these immune compromised individuals can lead to life threatening dissemination of infections.

Keywords: Allergic disease; Corticosteroids; Eczema; Elevated IgE; Primary immune deficiency.

Publication types

  • Review

MeSH terms

  • Diagnosis, Differential
  • Disease Management
  • Eczema / complications
  • Eczema / diagnosis
  • Eczema / immunology
  • Humans
  • Hypersensitivity / complications*
  • Hypersensitivity / diagnosis
  • Hypersensitivity / immunology*
  • Immunoglobulin E / immunology
  • Immunologic Deficiency Syndromes / complications*
  • Immunologic Deficiency Syndromes / diagnosis*
  • Immunologic Deficiency Syndromes / etiology
  • Immunologic Deficiency Syndromes / therapy
  • Infant
  • Infant, Newborn


  • Immunoglobulin E