A Randomized, Controlled Clinical Trial of Honey-Impregnated Dressing for Treating Diabetic Foot Ulcer

J Coll Physicians Surg Pak. 2015 Oct;25(10):721-5. doi: 10.2015/JCPSP.721725.


Objective: To investigate the effect of Beri-honey-impregnated dressing on diabetic foot ulcer and compare it with normal saline dressing.

Study design: A randomized, controlled trial.

Place and duration of study: Sughra Shafi Medical Complex, Narowal, Pakistan and Bhatti International Trust (BIT) Hospital, Affiliated with Central Park Medical College, Lahore, from February 2006 to February 2010.

Methodology: Patients with Wagner's grade 1 and 2 ulcers were enrolled. Those patients were divided in two groups; group A (n=179) treated with honey dressing and group B (n=169) treated with normal saline dressing. Outcome measures were calculated in terms of proportion of wounds completely healed (primary outcome), wound healing time, and deterioration of wounds. Patients were followed-up for a maximum of 120 days.

Results: One hundred and thirty six wounds (75.97%) out of 179 were completely healed with honey dressing and 97 (57.39%) out of 169 wtih saline dressing (p=0.001). The median wound healing time was 18.00 (6 - 120) days (Median with IQR) in group A and 29.00 (7 - 120) days (Median with IQR) in group B (p < 0.001).

Conclusion: The present results showed that honey is an effective dressing agent instead of conventional dressings, in treating patients of diabetic foot ulcer.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Apitherapy*
  • Bandages*
  • Diabetic Foot / complications
  • Diabetic Foot / drug therapy
  • Female
  • Foot Ulcer / etiology
  • Foot Ulcer / therapy*
  • Honey*
  • Humans
  • Male
  • Middle Aged
  • Pakistan
  • Prospective Studies
  • Sodium Chloride / therapeutic use*
  • Time Factors
  • Treatment Outcome
  • Wound Healing


  • Sodium Chloride