Mitochondrial Heat-Shock Protein hsp60 Is Essential for Assembly of Proteins Imported Into Yeast Mitochondria

Nature. 1989 Feb 16;337(6208):620-5. doi: 10.1038/337620a0.

Abstract

A nuclear encoded mitochondrial heat-shock protein hsp60 is required for the assembly into oligomeric complexes of proteins imported into the mitochondrial matrix. hsp60 is a member of the 'chaperonin' class of protein factors, which include the Escherichia coli groEL protein and the Rubisco subunit-binding protein of chloroplasts.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Fungal Proteins / genetics*
  • Genes
  • Genes, Fungal
  • Heat-Shock Proteins / genetics
  • Heat-Shock Proteins / physiology*
  • Mitochondria / metabolism*
  • Mutation
  • Plasmids
  • Protein Processing, Post-Translational*
  • Saccharomyces cerevisiae / genetics*
  • Saccharomyces cerevisiae / metabolism

Substances

  • Fungal Proteins
  • Heat-Shock Proteins