Suppressor of cytokine signaling-1 and chemokine (C-X-C Motif) receptor 3 expressions are associated with caseous necrosis in granulomas from patients with tuberculous lymphadenitis

J Microbiol Immunol Infect. 2016 Dec;49(6):984-987. doi: 10.1016/j.jmii.2015.08.018. Epub 2015 Sep 10.


We investigated the role of suppressor of cytokine signaling-1 (SOCS1) and SOCS3 molecules in lymph nodes from tuberculous lymphadenitis patients (LNTB). Fewer T cells were noted in LNTB cases, which also had raised chemokine (C-X-C motif) receptor 3 (CXCR3) levels. In addition, we observed a positive correlation between CXCR3 and SOCS1 expression. Our data suggest that upregulation of SOCS1 molecules may contribute to the dissemination of Mycobacterium tuberculosis from granulomas.

Keywords: caseous necrosis; granuloma; suppressor of cytokine signaling-1; tuberculous lymphadenitis.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Granuloma / microbiology
  • Humans
  • Lymphocyte Count
  • Macrophages / immunology
  • Middle Aged
  • Mycobacterium tuberculosis / metabolism*
  • Necrosis / pathology*
  • Receptors, CXCR3 / metabolism*
  • Suppressor of Cytokine Signaling 1 Protein / metabolism*
  • Suppressor of Cytokine Signaling 3 Protein / metabolism*
  • T-Lymphocytes / immunology
  • Tuberculosis, Lymph Node / pathology*
  • Young Adult


  • CXCR3 protein, human
  • Receptors, CXCR3
  • SOCS1 protein, human
  • SOCS3 protein, human
  • Suppressor of Cytokine Signaling 1 Protein
  • Suppressor of Cytokine Signaling 3 Protein