The presumed central nervous system effects of rocuronium in a neonate and its reversal with sugammadex

Paediatr Anaesth. 2016 Jan;26(1):109-11. doi: 10.1111/pan.12789. Epub 2015 Oct 12.

Abstract

We describe a 2-day-old male infant who received rocuronium as part of general anesthesia for a tracheal esophageal fistula repair. Postoperatively, he had prolonged central and peripheral neuromuscular blockade despite cessation of the rocuronium infusion several hours previously. This case discusses the presumed central nervous system effects of rocuronium in a neonate and its effective reversal with sugammadex.

Keywords: blood-brain barrier; neonate; rocuronium; sugammadex.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Androstanols / pharmacology*
  • Central Nervous System / drug effects*
  • Humans
  • Infant, Newborn
  • Male
  • Neuromuscular Blockade / methods*
  • Neuromuscular Nondepolarizing Agents / pharmacology*
  • Rocuronium
  • Sugammadex
  • gamma-Cyclodextrins / administration & dosage*

Substances

  • Androstanols
  • Neuromuscular Nondepolarizing Agents
  • gamma-Cyclodextrins
  • Sugammadex
  • Rocuronium