Diagnosis of Food Allergy

Pediatr Clin North Am. 2015 Dec;62(6):1393-408. doi: 10.1016/j.pcl.2015.07.009. Epub 2015 Sep 7.


The prevalence of food allergies has been on the increase over the last 2 decades. Diagnosing food allergies can be complicated, as there are multiple types that have distinct clinical and immunologic features. Food allergies are broadly classified into immunoglobulin E (IgE)-mediated, non-IgE-mediated, or mixed food allergic reactions. This review focuses on the clinical manifestations of the different categories of food allergies and the different tests available to guide the clinician toward an accurate diagnosis.

Keywords: Component testing; Elimination diets; Food allergy; IgE-mediated; Non–IgE-mediated; Oral food challenge; Skin-prick testing.

Publication types

  • Review

MeSH terms

  • Anaphylaxis / diagnosis
  • Anaphylaxis / immunology
  • Child
  • Diagnosis, Differential
  • Food Hypersensitivity / diagnosis*
  • Food Hypersensitivity / immunology
  • Humans
  • Immunoglobulin E / immunology
  • Immunologic Tests*
  • Medical History Taking
  • Physical Examination


  • Immunoglobulin E